Primary Identifier | MGI:2177655 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Fus |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A knock-in cassette containing a loxP-flanked neomycin gene followed by a human DDIT3 gene replaced exons 8 and 9. This allele expresses a fusion protein of FUS and Neo in which the neomycin sequences replace the RNA-binding C-terminal portion of the gene; the inserted DDIT3 gene is not expressed. |