| First Author | Kuroda M | Year | 2000 |
| Journal | EMBO J | Volume | 19 |
| Issue | 3 | Pages | 453-62 |
| PubMed ID | 10654943 | Mgi Jnum | J:60224 |
| Mgi Id | MGI:1352989 | Doi | 10.1093/emboj/19.3.453 |
| Citation | Kuroda M, et al. (2000) Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. EMBO J 19(3):453-62 |
| abstractText | TLS (also known as FUS) is an RNA-binding protein that contributes the N-terminal half of fusion oncoproteins implicated in the development of human liposarcomas and leukemias. Here we report that male mice homozygous for an induced mutation in TLS are sterile with a marked increase in the number of unpaired and mispaired chromosomal axes in pre-meiotic spermatocytes. Nuclear extracts from TLS(-/-) testes lack an activity capable of promoting pairing between homologous DNA sequences in vitro, and TLS(-/-) mice and embryonic fibroblasts exhibit increased sensitivity to ionizing irradiation. These results are consistent with a role for TLS in homologous DNA pairing and recombination. |
