| First Author | Trushina E | Year | 2006 |
| Journal | Behav Brain Res | Volume | 172 |
| Issue | 1 | Pages | 24-32 |
| PubMed ID | 16750274 | Mgi Jnum | J:110712 |
| Mgi Id | MGI:3640908 | Doi | 10.1016/j.bbr.2006.04.024 |
| Citation | Trushina E, et al. (2006) Neurological abnormalities in caveolin-1 knock out mice. Behav Brain Res 172(1):24-32 |
| abstractText | Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control. |
