| First Author | Klinger M | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 8 | Pages | 4581-9 |
| PubMed ID | 19342632 | Mgi Jnum | J:147746 |
| Mgi Id | MGI:3842044 | Doi | 10.4049/jimmunol.0900010 |
| Citation | Klinger M, et al. (2009) Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol 182(8):4581-9 |
| abstractText | OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of most naive T cells. The results are consistent with the selection of Treg cells and a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands. |
