| First Author | Tan J | Year | 2011 |
| Journal | Cancer Cell | Volume | 20 |
| Issue | 5 | Pages | 563-75 |
| PubMed ID | 22094252 | Mgi Jnum | J:178955 |
| Mgi Id | MGI:5300668 | Doi | 10.1016/j.ccr.2011.09.008 |
| Citation | Tan J, et al. (2011) CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis. Cancer Cell 20(5):563-75 |
| abstractText | Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; however, the underlying mechanisms remain elusive. Here, we show that chromobox homolog 8 (CBX8), a Polycomb Group protein that interacts with MLL-AF9 and TIP60, is required for MLL-AF9-induced transcriptional activation and leukemogenesis. Conversely, both CBX8 ablation and specific disruption of the CBX8 interaction by point mutations in MLL-AF9 abrogate HOX gene upregulation and abolish MLL-AF9 leukemic transformation. Surprisingly, Cbx8-deficient mice are viable and display no apparent hematopoietic defects. Together, our findings demonstrate that CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. |
