| First Author | Nasrallah K | Year | 2024 |
| Journal | Cell Rep | Volume | 43 |
| Issue | 7 | Pages | 114382 |
| PubMed ID | 38905101 | Mgi Jnum | J:353440 |
| Mgi Id | MGI:7709042 | Doi | 10.1016/j.celrep.2024.114382 |
| Citation | Nasrallah K, et al. (2024) Retrograde adenosine/A(2A) receptor signaling facilitates excitatory synaptic transmission and seizures. Cell Rep 43(7):114382 |
| abstractText | Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signaling, the mechanisms remain poorly understood. Here, we identified adenosine/A(2A) receptor (A(2A)R) as a retrograde signaling pathway underlying presynaptic long-term potentiation (LTP) at a hippocampal excitatory circuit critically involved in memory and epilepsy. Transient burst activity of a single dentate granule cell induced LTP of mossy cell synaptic inputs, a BDNF/TrkB-dependent form of plasticity that facilitates seizures. Postsynaptic TrkB activation released adenosine from granule cells, uncovering a non-conventional BDNF/TrkB signaling mechanism. Moreover, presynaptic A(2A)Rs were necessary and sufficient for LTP. Lastly, seizure induction released adenosine in a TrkB-dependent manner, while removing A(2A)Rs or TrkB from the dentate gyrus had anti-convulsant effects. By mediating presynaptic LTP, adenosine/A(2A)R retrograde signaling may modulate dentate gyrus-dependent learning and promote epileptic activity. |
