| First Author | Pradhan J | Year | 2012 |
| Journal | Neurosci Lett | Volume | 531 |
| Issue | 1 | Pages | 30-4 |
| PubMed ID | 23041045 | Mgi Jnum | J:197501 |
| Mgi Id | MGI:5493199 | Doi | 10.1016/j.neulet.2012.09.049 |
| Citation | Pradhan J, et al. (2012) Long term depression of MNTB-LSO synapses is expressed postsynaptically in developing circling mice. Neurosci Lett 531(1):30-4 |
| abstractText | Early onset long term depression (LTD) during the first postnatal week has rarely been demonstrated at the medial nucleus of trapezoid body (MNTB) - lateral superior olive (LSO) synapses in spite of many favorable conditions, such as depolarizing synapses and glutamate co-release from MNTB terminals. Thus, we tested the early expression of LTD at MNTB-LSO synapses during the first postnatal week using circling mice, whose main transmitter is glutamate at MNTB-LSO synapses. Tetanic stimulation on MNTB elicited LTD of postsynaptic currents recorded at LSO neurons in P0-P3 homozygous (cir/cir) mice (45.8 +/- 0.3% of the control, n = 7) and heterozygous (+/cir) mice (43.3 +/- 0.4% of the control, n = 7). The magnitude of LTD decreased in P8-P12 heterozygous (+/cir) mice (84.5 +/- 0.3% of the control, n = 7), but was maintained in P8-P12 homozygous (cir/cir) mice (38.2 +/- 0.3% of the control, n = 9). Glutamatergic LTD observed in homozygous (cir/cir) mice and glycinergic LTD observed heterozygous (+/cir) mice showed similar pattern of change. As currents induced by the pressure application of glycine on LSO neurons were reduced by tetanic stimulation in P0-P3 heterozygous (+/cir) mice, LTD was thought to occur at postsynaptic sites. Our results suggest that LTD might occur in vivo and participate in the synaptic silencing and strengthening of MNTB-LSO synapses, which is most active during the first postnatal week. |
