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Allele : Brca2<tm1Cbl> breast cancer 2, early onset; targeted mutation 1, Chester Beatty Laboratories

Primary Identifier  MGI:2177226 Allele Type  Targeted
Attribute String  Null/knockout Gene  Brca2
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin selection cassette was inserted into exon 11 at position 6038. RT-PCR analysis on RNA derived from homozygous animals demonstrated that a partial transcript is made from this allele. Western blot analysis confirmed that no protein with an intact carboxy-terminus was expressed from this allele, but the authors do not rule out the possiblilty that a partial product could be made.
  • mutations:
  • Insertion
  • synonyms:
  • Brca2<Tr2014>,
  • Brca2<Tr2014>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele