| First Author | Ota MS | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 496 |
| Issue | 2 | Pages | 324-327 |
| PubMed ID | 29337060 | Mgi Jnum | J:271440 |
| Mgi Id | MGI:6276765 | Doi | 10.1016/j.bbrc.2018.01.073 |
| Citation | Ota MS, et al. (2018) Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6. Biochem Biophys Res Commun 496(2):324-327 |
| abstractText | Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur in moderate prevalence in C57BL/6 mice; however, very little is known about the occurrence of such grooves. In the present study, we observed age-dependent groove formation in C57BL/6 mice up to 26 months after birth and found that not only the frequency of the appearance of incisor grooves but also the number of grooves increased in an age-dependent manner. We examined the molecular mechanisms of age-dependent groove formation by performing DNA microarray analysis of the incisors of 12-month-old (12M) and 24-month-old (24M) mice. Amelx, encoding the major enamel matrix protein AMELOGENIN, was identified as a 12M-specific gene. Comparing with wild-type mice, the maxillary incisors of Amelx(-/-) mutants indicated the increase of the frequency and number of labial grooves. These findings suggested that the Amelx gene impacts the age-dependent appearance of the labial incisor groove in C57BL/6 mice. |
