| First Author | Pan BX | Year | 2008 |
| Journal | J Neurosci | Volume | 28 |
| Issue | 9 | Pages | 2089-98 |
| PubMed ID | 18305243 | Mgi Jnum | J:132855 |
| Mgi Id | MGI:3777053 | Doi | 10.1523/JNEUROSCI.5156-07.2008 |
| Citation | Pan BX, et al. (2008) Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci 28(9):2089-98 |
| abstractText | Auditory fear conditioning, a model for fear learning, is thought to be mediated by synaptic changes in the cortical and thalamic inputs to the lateral amygdala (LA); however, the specific roles of both pathways are still debated. Here, we report that a CaMKII-alpha-Cre-mediated knock-out (KO) of the rap1a and rap1b genes impaired synaptic plasticity and increased basal synaptic transmission in the cortical but not thalamic input to the LA via presynaptic changes: increases in glutamate release probability and the number of glutamate quanta released by a single action potential. Moreover, KO mice with alterations in the cortico-LA pathway had impaired fear learning, which could be rescued by training with a more aversive unconditional stimulus. These results suggest that Rap1-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. |
