| First Author | Conroy JL | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 3 | Pages | 284-6 |
| PubMed ID | 20139973 | Mgi Jnum | J:158630 |
| Mgi Id | MGI:4439247 | Doi | 10.1038/nn.2497 |
| Citation | Conroy JL, et al. (2010) Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nat Neurosci 13(3):284-6 |
| abstractText | To assess the importance of brain cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine. |
