| First Author | Zhuang Y | Year | 1996 |
| Journal | Mol Cell Biol | Volume | 16 |
| Issue | 6 | Pages | 2898-905 |
| PubMed ID | 8649400 | Mgi Jnum | J:43324 |
| Mgi Id | MGI:1097504 | Doi | 10.1128/mcb.16.6.2898 |
| Citation | Zhuang Y, et al. (1996) B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol 16(6):2898-905 |
| abstractText | B-lymphocyte development requires the basic helix-loop-helix proteins encoded by the E2A gene. In this study, the control mechanism of E2A was further explored by disruption of the E2A-related genes, E2-2 and HEB. In contrast to E2A, E2-2 and HEB are not essential for the establishment of the B-cell lineage. However, both E2-2 and HEB are required for the generation of the normal numbers of pro-B cells in mouse embryos. Breeding tests among mice carrying different mutations revealed that E2-2 and HEB interact with E2A in many developmental processes including generation of B cells. Specifically, mice transheterozygous for any two mutations of these three genes produced fewer pro-B cells than the singly heterozygous littermates. This study indicates that B-cell development is dependent not only on an essential function provided by the E2A gene but also on a combined dosage set by E2A, E2-2, and HEB. |
