| First Author | Kee BL | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 3 | Pages | 242-7 |
| PubMed ID | 11224524 | Mgi Jnum | J:118964 |
| Mgi Id | MGI:3700875 | Doi | 10.1038/85303 |
| Citation | Kee BL, et al. (2001) Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta. Nat Immunol 2(3):242-7 |
| abstractText | E proteins function in many developmental processes and are essential for the formation of lymphocyte progenitors. However, it is not known whether E proteins regulate lymphocyte survival, proliferation or differentiation or how their activity is regulated during lymphocyte development. We show here a role for Id3, an inhibitor of E protein activity, in the induction of apoptosis and growth arrest. Id3 is induced in response to transforming growth factor beta (TGF-beta), a pleiotropic cytokine that inhibits the growth and survival of normal and transformed lymphocyte progenitors. In the absence of Id3, the response of lymphocyte progenitors to TGF-beta is perturbed, which indicates that Id3 is a mediator of this response. Our data show a key role for E proteins in lymphocyte survival and link the activity of E proteins, and their antagonists, to members of the TGF-beta family of cytokines. |
