| First Author | Fabre V | Year | 2011 |
| Journal | Eur Neuropsychopharmacol | Volume | 21 |
| Issue | 1 | Pages | 33-44 |
| PubMed ID | 21075611 | Mgi Jnum | J:285538 |
| Mgi Id | MGI:6400177 | Doi | 10.1016/j.euroneuro.2010.10.004 |
| Citation | Fabre V, et al. (2011) Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1. Eur Neuropsychopharmacol 21(1):33-44 |
| abstractText | Transcriptome analyses were performed in the anterior raphe area of mutant mice deficient in the serotonin transporter (5-HTT KO) or overexpressing this protein (5-HTT TG), which exhibit opposite changes in anxiety-related behavior. Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice. Expression of the gene encoding cocaine-and-amphetamine-related-peptide, which colocalizes with urocortin 1, was also increased in 5-HTT TG mutants. Real-time RT-PCR confirmed these data and immunoautoradiographic labeling showed that parallel changes in neuropeptide levels were confined to the non-preganglionic Edinger-Westphal nucleus. Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice. |
