| First Author | Rioux A | Year | 1999 |
| Journal | Neurosci Lett | Volume | 262 |
| Issue | 2 | Pages | 113-6 |
| PubMed ID | 10203244 | Mgi Jnum | J:57213 |
| Mgi Id | MGI:1344094 | Doi | 10.1016/s0304-3940(99)00049-x |
| Citation | Rioux A, et al. (1999) Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter. Neurosci Lett 262(2):113-6 |
| abstractText | The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT. Autoradiographic labeling of these receptors by the selective antagonist [3H]MDL 100,907 and saturation experiments with cortical membranes revealed: (1) a new localization of these receptors in the external field of striatum (possibly in striosomes); (2) regional variations in adaptive changes in the density of 5-HT2A receptors in 5-HT(-/-) mutants (-30-40% in the claustrum, cerebral cortex and lateral striatum; no significant change in the striatum core) as compared to wild-type mice. |
