| First Author | Jackson CR | Year | 2011 |
| Journal | Eur J Neurosci | Volume | 34 |
| Issue | 1 | Pages | 57-64 |
| PubMed ID | 21676039 | Mgi Jnum | J:177942 |
| Mgi Id | MGI:5296719 | Doi | 10.1111/j.1460-9568.2011.07734.x |
| Citation | Jackson CR, et al. (2011) Dopamine D(4) receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina. Eur J Neurosci 34(1):57-64 |
| abstractText | In the mammalian retina, dopamine binding to the dopamine D receptor (DR) affects a light-sensitive pool of cyclic AMP by negatively coupling to the type 1 adenylyl cyclase (AC1). AC1 is the primary enzyme controlling cyclic AMP production in dark-adapted photoreceptors. A previous study demonstrated that expression of the gene encoding AC1, Adcy1, is downregulated in mice lacking Drd4, the gene encoding the DR. The present investigation provides evidence that DR activation entrains the circadian rhythm of Adcy1 mRNA expression. Diurnal and circadian rhythms of Drd4 and Adcy1 mRNA levels were observed in wild-type mouse retina. Also, rhythms in the Ca(2)-stimulated AC activity and cyclic AMP levels were observed. However, these rhythmic activities were damped or undetectable in mice lacking the DR. Pharmacologically activating the DR 4 h before its normal stimulation at light onset in the morning advances the phase of the Adcy1 mRNA expression pattern. These data demonstrate that stimulating the DR is essential in maintaining the normal rhythmic production of AC1 from transcript to enzyme activity. Thus, dopamine/DR signaling is a novel zeitgeber that entrains the rhythm of Adcy1 expression and, consequently, modulates the rhythmic synthesis of cyclic AMP in mouse retina. |
