| First Author | Letiembre M | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 12 | Pages | 8397-401 |
| PubMed ID | 16299338 | Mgi Jnum | J:104301 |
| Mgi Id | MGI:3611644 | Doi | 10.1128/IAI.73.12.8397-8401.2005 |
| Citation | Letiembre M, et al. (2005) Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes. Infect Immun 73(12):8397-401 |
| abstractText | Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2-/- PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN. |
