| First Author | Gomes MS | Year | 2004 |
| Journal | Immunology | Volume | 111 |
| Issue | 2 | Pages | 179-85 |
| PubMed ID | 15027903 | Mgi Jnum | J:113756 |
| Mgi Id | MGI:3687615 | Doi | 10.1111/j.0019-2805.2003.01807.x |
| Citation | Gomes MS, et al. (2004) Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium. Immunology 111(2):179-85 |
| abstractText | The role of the Toll-like receptor (TLR)-2 in the generation of protective immunity to Mycobacterium avium was evaluated using gene-disrupted mice. TLR-2-/- mice were more susceptible than wild-type C57Bl/6 mice to M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis. In contrast, the elimination of non-virulent strains was not affected by the mutation. The generation of interferon-gamma (IFN-gamma)-producing T cells and the expression of the interleukin-12 p40 gene were reduced in TLR-2-deficient mice as compared to C57Bl/6 mice early during infection with M. avium strain 2447. The generation of protective CD4+ T cells was also compromised in the mutated mice as compared with the controls. Our data show that TLR-2 is required for optimal immunity against certain virulent M. avium strains. |
