| First Author | Yamazaki S | Year | 2018 |
| Journal | J Immunol | Volume | 200 |
| Issue | 1 | Pages | 119-129 |
| PubMed ID | 29158419 | Mgi Jnum | J:256418 |
| Mgi Id | MGI:6108092 | Doi | 10.4049/jimmunol.1701056 |
| Citation | Yamazaki S, et al. (2018) Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin. J Immunol 200(1):119-129 |
| abstractText | Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity. |
