| First Author | Eltokhi A | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 11 | Pages | 108116 |
| PubMed ID | 37876813 | Mgi Jnum | J:342019 |
| Mgi Id | MGI:7544653 | Doi | 10.1016/j.isci.2023.108116 |
| Citation | Eltokhi A, et al. (2023) Distinct effects of AMPAR subunit depletion on spatial memory. iScience 26(11):108116 |
| abstractText | Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice (Gria1/3(-/-)) and conditional knockouts lacking GluA1 and GluA3 AMPAR subunits specifically from principal cells across the forebrain (Gria1/3(DeltaFb)). In both models, loss of GluA1 and GluA3 resulted in reduced hippocampal GluA2 and increased levels of the NMDAR subunit GluN2A. Electrically-evoked AMPAR-mediated EPSPs were greatly diminished, and there was an absence of tetanus-induced LTP. Gria1/3(-/-) mice showed premature mortality. Gria1/3(DeltaFb) mice were viable, and their memory performance could be analyzed. In the Morris water maze (MWM), Gria1/3(DeltaFb) mice showed profound long-term memory deficits, in marked contrast to the normal MWM learning previously seen in single Gria1(-/-) and Gria3(-/-) knockout mice. Our results suggest a redundancy of function within the pool of available ionotropic glutamate receptors for long-term spatial memory performance. |
