| First Author | Lim Y | Year | 2011 |
| Journal | J Neurosci | Volume | 31 |
| Issue | 27 | Pages | 10076-87 |
| PubMed ID | 21734300 | Mgi Jnum | J:174555 |
| Mgi Id | MGI:5139963 | Doi | 10.1523/JNEUROSCI.0618-11.2011 |
| Citation | Lim Y, et al. (2011) alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J Neurosci 31(27):10076-87 |
| abstractText | Abnormally accumulated alpha-synuclein (alpha-syn) is a pathological hallmark of Lewy body-related disorders such as Parkinson''s disease (PD) and dementia with Lewy body disease (DLB). However, it is not well understood whether and how abnormal accumulation of alpha-syn leads to cognitive impairment or dementia in PD and DLB. Furthermore, it is not known whether targeted removal of alpha-syn pathology can reverse cognitive decline. Here, we found that the distribution of alpha-syn pathology in an inducible alpha-syn transgenic mouse model recapitulates that in human DLB. Abnormal accumulation of alpha-syn in the limbic system, particularly in the hippocampus, correlated with memory impairment and led to structural synaptic deficits. Furthermore, when alpha-syn expression was suppressed, we observed partial clearing of pre-existing alpha-syn pathology and reversal of structural synaptic defects, resulting in an improvement in memory function. |
