| First Author | Lee KS | Year | 2024 |
| Journal | Neuron | PubMed ID | 39111305 |
| Mgi Jnum | J:353971 | Mgi Id | MGI:7714455 |
| Doi | 10.1016/j.neuron.2024.07.005 | Citation | Lee KS, et al. (2024) Transformation of neural coding for vibrotactile stimuli along the ascending somatosensory pathway. Neuron |
| abstractText | In mammals, action potentials fired by rapidly adapting mechanosensitive afferents are known to reliably time lock to the cycles of a vibration. How and where along the ascending neuraxis is the peripheral afferent temporal code transformed into a rate code are currently not clear. Here, we probed the encoding of vibrotactile stimuli with electrophysiological recordings along major stages of the ascending somatosensory pathway in mice. We discovered the main transformation step was identified at the level of the thalamus, and parvalbumin-positive interneurons in thalamic reticular nucleus participate in sharpening frequency selectivity and in disrupting the precise spike timing. When frequency-specific microstimulation was applied within the brainstem, it generated frequency selectivity reminiscent of real vibration responses in the somatosensory cortex and could provide informative and robust signals for learning in behaving mice. Taken together, these findings could guide biomimetic stimulus strategies to activate specific nuclei along the ascending somatosensory pathway for neural prostheses. |
