| First Author | Yetman MJ | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 44 | Pages | 17335-41 |
| PubMed ID | 24174666 | Mgi Jnum | J:204201 |
| Mgi Id | MGI:5529775 | Doi | 10.1523/JNEUROSCI.1917-13.2013 |
| Citation | Yetman MJ, et al. (2013) Wild-type neural progenitors divide and differentiate normally in an amyloid-rich environment. J Neurosci 33(44):17335-41 |
| abstractText | Adult neurogenesis is modulated by a balance of extrinsic signals and intrinsic responses that maintain production of new granule cells in the hippocampus. Disorders that disrupt the proliferative niche can impair this process, and alterations in adult neurogenesis have been described in human autopsy tissue and transgenic mouse models of Alzheimer's disease. Because exogenous application of aggregated Abeta peptide is neurotoxic in vitro and extracellular Abeta deposits are the main pathological feature recapitulated by mouse models, cell-extrinsic effects of Abeta accumulation were thought to underlie the breakdown of hippocampal neurogenesis observed in Alzheimer's models. We tested this hypothesis using a bigenic mouse in which transgenic expression of APP was restricted to mature projection neurons. These mice allowed us to examine how wild-type neural progenitor cells responded to high levels of Abeta released from neighboring granule neurons. We find that the proliferation, determination, and survival of hippocampal adult-born granule neurons are unaffected in the APP bigenic mice, despite abundant amyloid pathology and robust neuroinflammation. Our findings suggest that Abeta accumulation is insufficient to impair adult hippocampal neurogenesis, and that factors other than amyloid pathology may account for the neurogenic deficits observed in transgenic models with more widespread APP expression. |
