| First Author | Reisel D | Year | 2002 |
| Journal | Nat Neurosci | Volume | 5 |
| Issue | 9 | Pages | 868-73 |
| PubMed ID | 12195431 | Mgi Jnum | J:78706 |
| Mgi Id | MGI:2385967 | Doi | 10.1038/nn910 |
| Citation | Reisel D, et al. (2002) Spatial memory dissociations in mice lacking GluR1. Nat Neurosci 5(9):868-73 |
| abstractText | Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze reference memory performance depended on hippocampal function in both wild-type and mutant mice; bilateral hippocampal lesions profoundly impaired performance on both tasks, to a similar extent in both groups. These results suggest that different forms of hippocampus-dependent spatial memory involve different aspects of neural processing within the hippocampus. |
