| First Author | Chang JT | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 4 | Pages | 492-504 |
| PubMed ID | 21497118 | Mgi Jnum | J:171335 |
| Mgi Id | MGI:4949764 | Doi | 10.1016/j.immuni.2011.03.017 |
| Citation | Chang JT, et al. (2011) Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division. Immunity 34(4):492-504 |
| abstractText | Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells. |
