| First Author | Tavernier SJ | Year | 2017 |
| Journal | Nat Cell Biol | Volume | 19 |
| Issue | 6 | Pages | 698-710 |
| PubMed ID | 28459443 | Mgi Jnum | J:246202 |
| Mgi Id | MGI:5921024 | Doi | 10.1038/ncb3518 |
| Citation | Tavernier SJ, et al. (2017) Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival. Nat Cell Biol 19(6):698-710 |
| abstractText | The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic cells (cDC1s) results in functional alterations without affecting cell survival. However, in mucosal cDC1s, loss of XBP1 impaired survival in a tissue-specific manner-while lung cDC1s die, intestinal cDC1s survive. This was not caused by differential activation of ER stress cell-death regulators CHOP or JNK. Rather, survival of intestinal cDC1s was associated with their ability to shut down protein synthesis through a protective integrated stress response and their marked increase in regulated IRE1-dependent messenger RNA decay. Furthermore, loss of IRE1 endonuclease on top of XBP1 led to cDC1 loss in the intestine. Thus, mucosal DCs differentially mount ATF4- and IRE1-dependent adaptive mechanisms to survive in the face of ER stress. |
