| First Author | Chever O | Year | 2016 |
| Journal | Sci Signal | Volume | 9 |
| Issue | 410 | Pages | ra6 |
| PubMed ID | 26758214 | Mgi Jnum | J:259994 |
| Mgi Id | MGI:6141761 | Doi | 10.1126/scisignal.aad3066 |
| Citation | Chever O, et al. (2016) Astroglial networks promote neuronal coordination. Sci Signal 9(410):ra6 |
| abstractText | Astrocytes interact with neurons to regulate network activity. Although the gap junction subunits connexin 30 and connexin 43 mediate the formation of extensive astroglial networks that cover large functional neuronal territories, their role in neuronal synchronization remains unknown. Using connexin 30- and connexin 43-deficient mice, we showed that astroglial networks promoted sustained population bursts in hippocampal slices by setting the basal active state of neurons. Astroglial networks limited excessive neuronal depolarization induced by spontaneous synaptic activity, increased neuronal release probability, and favored the recruitment of neurons during bursting, thus promoting the coordinated activation of neuronal networks. In vivo, this sustained neuronal coordination translated into increased severity of acutely evoked epileptiform events and convulsive behavior. These results revealed that connexin-mediated astroglial networks synchronize bursting of neuronal assemblies, which can exacerbate pathological network activity and associated behavior. Our data thus provide molecular and biophysical evidence predicting selective astroglial gap junction inhibitors as anticonvulsive drugs. |
