| First Author | Chen RZ | Year | 2006 |
| Journal | Brain Res | Volume | 1108 |
| Issue | 1 | Pages | 176-8 |
| PubMed ID | 16828068 | Mgi Jnum | J:112571 |
| Mgi Id | MGI:3662792 | Doi | 10.1016/j.brainres.2006.06.006 |
| Citation | Chen RZ, et al. (2006) Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors. Brain Res 1108(1):176-8 |
| abstractText | We used mu-opioid receptor-deficient (MOR-/-) mice to determine the effects of the CB1 cannabinoid receptor inverse agonist AM251 on feeding in the absence of MOR signaling. A single dose of AM251 at 0.6, 2 or 6 mg/kg caused similar dose-dependent suppression of food intake in wild-type and MOR-/- mice. Administration of AM251 at 3 mg/kg/day for 9 consecutive days also led to a similar reduction ( approximately 8%) in body weight in wild-type and MOR-/- mice. Our results suggest that MOR signaling is not necessary for cannabinoid-mediated effects on feeding and that physiological antagonism of opioid receptor tone might be required for the observed synergistic effects of a CB1 inverse agonist and an opioid receptor antagonist on feeding. |
