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Allele : Erbb2<tm1Mul> erb-b2 receptor tyrosine kinase 2; targeted mutation 1, William Muller

Primary Identifier  MGI:2179176 Allele Type  Targeted
Gene  Erbb2 Transmission  Germline
Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+> Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 1 was targeted with a PGK-neo cassette preceded by a point mutation at lysine 757 (K757M) destroying the kinase activity of the gene product. Homozygous mutant embyros were identified by genotype analysis at E11.5-E13.5.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • erbB-2<KD>,
  • erbB-2<KD>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories

Trail: Allele