| First Author | Bellomo D | Year | 2000 |
| Journal | Circ Res | Volume | 86 |
| Issue | 2 | Pages | E29-35 |
| PubMed ID | 10666423 | Mgi Jnum | J:60503 |
| Mgi Id | MGI:1353384 | Doi | 10.1161/01.res.86.2.e29 |
| Citation | Bellomo D, et al. (2000) Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 86(2):E29-35 |
| abstractText | Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-)). Unlike Vegfa knockout mice, which die during embryogenesis, Vegfb(-/-) mice are healthy and fertile. Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis. |
