| First Author | Horai R | Year | 2007 |
| Journal | Immunity | Volume | 27 |
| Issue | 5 | Pages | 775-85 |
| PubMed ID | 18031697 | Mgi Jnum | J:127611 |
| Mgi Id | MGI:3763984 | Doi | 10.1016/j.immuni.2007.09.012 |
| Citation | Horai R, et al. (2007) Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27(5):775-85 |
| abstractText | Mice deficient in the Tec kinase Itk develop a large population of CD8(+) T cells with properties, including expression of memory markers, rapid production of cytokines, and dependence on Interleukin-15, resembling NKT and other innate T cell lineages. Like NKT cells, these CD8(+) T cells can be selected on hematopoietic cells. We demonstrate that these CD8(+) T cell phenotypes resulted from selection on hematopoietic cells-forcing selection on the thymic stroma reduced the number and innate phenotypes of mature Itk-deficient CD8(+) T cells. We further show that, similar to NKT cells, selection of innate-type CD8(+) T cells in Itk(-/-) mice required the adaptor SAP. Acquisition of their innate characteristics, however, required CD28. Our results suggest that SAP and Itk reciprocally regulate selection of innate and conventional CD8(+) T cells on hematopoietic cells and thymic epithelium, respectively, whereas CD28 regulates development of innate phenotypes resulting from selection on hematopoietic cells. |
