| First Author | Sakimoto T | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 25-26 | Pages | 3674-80 |
| PubMed ID | 18840438 | Mgi Jnum | J:143420 |
| Mgi Id | MGI:3826909 | Doi | 10.1016/j.febslet.2008.09.052 |
| Citation | Sakimoto T, et al. (2008) Collagen XVIII and corneal reinnervation following keratectomy. FEBS Lett 582(25-26):3674-80 |
| abstractText | The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1(-/-)). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1(-/-) mouse corneas. Following keratectomy, col18a1(-/-) mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding. |
