| First Author | Clotman F | Year | 2005 |
| Journal | Genes Dev | Volume | 19 |
| Issue | 16 | Pages | 1849-54 |
| PubMed ID | 16103213 | Mgi Jnum | J:100352 |
| Mgi Id | MGI:3588024 | Doi | 10.1101/gad.340305 |
| Citation | Clotman F, et al. (2005) Control of liver cell fate decision by a gradient of TGFbeta signaling modulated by Onecut transcription factors. Genes Dev 19(16):1849-54 |
| abstractText | During liver development, hepatocytes and biliary cells differentiate from common progenitors called hepatoblasts. The factors that control hepatoblast fate decision are unknown. Here we report that a gradient of activin/TGFbeta signaling controls hepatoblast differentiation. High activin/TGFbeta signaling is required near the portal vein for differentiation of biliary cells. The Onecut transcription factors HNF-6 and OC-2 inhibit activin/TGFbeta signaling in the parenchyma, and this allows normal hepatocyte differentiation. In the absence of Onecut factors, the shape of the activin/TGFbeta gradient is perturbed and the hepatoblasts differentiate into hybrid cells that display characteristics of both hepatocytes and biliary cells. Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages. |
