| First Author | Sawa S | Year | 2010 |
| Journal | Science | Volume | 330 |
| Issue | 6004 | Pages | 665-9 |
| PubMed ID | 20929731 | Mgi Jnum | J:288222 |
| Mgi Id | MGI:6430962 | Doi | 10.1126/science.1194597 |
| Citation | Sawa S, et al. (2010) Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science 330(6004):665-9 |
| abstractText | Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORgammat, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORgammat(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORgammat(+) precursors. The fate of RORgammat(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORgammat(+) T cells, however, RORgammat(+) ILCs develop in the absence of microbiota. Our study indicates that RORgammat(+) ILCs evolve to preempt intestinal colonization by microbial symbionts. |
