| First Author | Köntgen F | Year | 1995 |
| Journal | Genes Dev | Volume | 9 |
| Issue | 16 | Pages | 1965-77 |
| PubMed ID | 7649478 | Mgi Jnum | J:28435 |
| Mgi Id | MGI:76052 | Doi | 10.1101/gad.9.16.1965 |
| Citation | Kontgen F, et al. (1995) Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 9(16):1965-77 |
| abstractText | The c-rel proto-oncogene, which is expressed predominantly in hemopoietic cells encodes a subunit of the NF-kappa B-like family of transcription factors. In mice with an inactivated c-rel gene, whereas development of cells from all hemopoietic lineages appeared normal, humoral immunity was impaired and mature B and T cells were found to be unresponsive to most mitogenic stimuli. Phorbol ester and calcium ionophore costimulation, in contrast to certain membrane receptor-mediated signals, overcame the T cell-proliferative defect, demonstrating that T cell proliferation occurs by Rel-dependent and -independent mechanisms. The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function. |
