| First Author | Cheng QJ | Year | 2021 |
| Journal | Science | Volume | 372 |
| Issue | 6548 | Pages | 1349-1353 |
| PubMed ID | 34140389 | Mgi Jnum | J:323815 |
| Mgi Id | MGI:6881643 | Doi | 10.1126/science.abc0269 |
| Citation | Cheng QJ, et al. (2021) NF-kappaB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science 372(6548):1349-1353 |
| abstractText | The epigenome of macrophages can be reprogrammed by extracellular cues, but the extent to which different stimuli achieve this is unclear. Nuclear factor kappaB (NF-kappaB) is a transcription factor that is activated by all pathogen-associated stimuli and can reprogram the epigenome by activating latent enhancers. However, we show that NF-kappaB does so only in response to a subset of stimuli. This stimulus specificity depends on the temporal dynamics of NF-kappaB activity, in particular whether it is oscillatory or non-oscillatory. Non-oscillatory NF-kappaB opens chromatin by sustained disruption of nucleosomal histone-DNA interactions, enabling activation of latent enhancers that modulate expression of immune response genes. Thus, temporal dynamics can determine a transcription factor's capacity to reprogram the epigenome in a stimulus-specific manner. |
