| First Author | Mallo M | Year | 1995 |
| Journal | Dev Dyn | Volume | 204 |
| Issue | 3 | Pages | 338-47 |
| PubMed ID | 8573724 | Mgi Jnum | J:29516 |
| Mgi Id | MGI:77048 | Doi | 10.1002/aja.1002040311 |
| Citation | Mallo M, et al. (1995) Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn 204(3):338-47 |
| abstractText | The Grg gene encodes a 197 amino acid protein homologous to the amino-terminal domain of the product of the groucho gene of the Drosophila Enhancer of split complex. Analysis with a polyclonal antisera specific for the Grg protein revealed that Grg is a 25 kd nuclear protein that can participate in specific protein-protein interactions. A null mutation of the Grg gene was constructed by gene targeting. Mice homozygous for this mutation completed embryogenesis and were born, but exhibited varying degrees of post-natal growth deficiency. No dosage-sensitive genetic interaction was detected between the Notch1 and Grg genes in mice heterozygous for a Notch1 mutant allele and homozygous for the Grg null mutation. |
