| First Author | Westphal S | Year | 2008 |
| Journal | Am J Pathol | Volume | 172 |
| Issue | 3 | Pages | 671-80 |
| PubMed ID | 18258848 | Mgi Jnum | J:132012 |
| Mgi Id | MGI:3774955 | Doi | 10.2353/ajpath.2008.070393 |
| Citation | Westphal S, et al. (2008) Resistance of chemokine receptor 6-deficient mice to yersinia enterocolitica infection: evidence of defective m-cell formation in vivo. Am J Pathol 172(3):671-80 |
| abstractText | M cells, specialized cells within Peyer's patches (PPs), are reduced in number in chemokine receptor 6 (CCR6)-deficient mice. The pathogenic microorganism Yersinia enterocolitica exploits M cells for the purpose of mucosal tissue invasion exclusively through PPs. The aim of this study was to evaluate the course of yersiniosis in CCR6-deficient mice and to investigate whether these mice might be used as an in vivo model to determine M-cell function. After oral challenge with Y. enterocolitica, control mice suffered from lethal septic infection whereas CCR6-deficient mice showed very limited symptoms of infection. Immunohistochemical analysis demonstrated PP invasion by Y. enterocolitica in control mice whereas no bacteria could be found in CCR6-deficient mice. In addition, a significant induction of proinflammatory cytokines could be found in control mice whereas proinflammatory cytokine levels in CCR6-deficient mice remained unchanged. In contrast, intraperitoneal infection resulted in severe systemic yersiniosis in both mouse groups. Abrogated oral Y. enterocolitica infection in CCR6-deficient mice demonstrates the importance of CCR6 expression in the physiological and pathological immune responses generated within PPs by influencing M-cell differentiation, underscoring the important role of M cells in the process of microbial uptake. CCR6-deficient mice may therefore represent a suitable model for the study of M-cell function in vivo. |
