| First Author | Mancino A | Year | 2013 |
| Journal | EMBO J | Volume | 32 |
| Issue | 6 | Pages | 816-28 |
| PubMed ID | 23422957 | Mgi Jnum | J:195312 |
| Mgi Id | MGI:5477882 | Doi | 10.1038/emboj.2013.28 |
| Citation | Mancino A, et al. (2013) I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J 32(6):816-28 |
| abstractText | Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming and activation of naive T cells is critical for development of new improved vaccines and understanding the pathogenesis of autoimmune diseases. The serine/threonine kinase IKKalpha (CHUK) has previously been shown to have anti-inflammatory activity and inhibit innate immunity. Here, we show that IKKalpha is required in DC for priming antigen-specific T cells and acquired immunity to the human pathogen Listeria monocytogenes. We describe a new role for IKKalpha in regulation of IRF3 activity and the functional maturation of DC. This presents a unique role for IKKalpha in dampening inflammation while simultaneously promoting adaptive immunity that could have important implications for the development of new vaccine adjuvants and treatment of autoimmune diseases. |
