| First Author | Ganeff C | Year | 2011 |
| Journal | Mol Cell Biol | Volume | 31 |
| Issue | 21 | Pages | 4319-34 |
| PubMed ID | 21896778 | Mgi Jnum | J:178327 |
| Mgi Id | MGI:5298150 | Doi | 10.1128/MCB.05033-11 |
| Citation | Ganeff C, et al. (2011) Induction of the alternative NF-kappaB pathway by lymphotoxin alphabeta (LTalphabeta) relies on internalization of LTbeta receptor. Mol Cell Biol 31(21):4319-34 |
| abstractText | Several tumor necrosis factor receptor (TNFR) family members activate both the classical and the alternative NF-kappaB pathways. However, how a single receptor engages these two distinct pathways is still poorly understood. Using lymphotoxin beta receptor (LTbetaR) as a prototype, we showed that activation of the alternative, but not the classical, NF-kappaB pathway relied on internalization of the receptor. Further molecular analyses revealed a specific cytosolic region of LTbetaR essential for its internalization, TRAF3 recruitment, and p100 processing. Interestingly, we found that dynamin-dependent, but clathrin-independent, internalization of LTbetaR appeared to be required for the activation of the alternative, but not the classical, NF-kappaB pathway. In vivo, ligand-induced internalization of LTbetaR in mesenteric lymph node stromal cells correlated with induction of alternative NF-kappaB target genes. Thus, our data shed light on LTbetaR cellular trafficking as a process required for specific biological functions of NF-kappaB. |
