| First Author | Staber JM | Year | 2016 |
| Journal | PLoS One | Volume | 11 |
| Issue | 5 | Pages | e0154857 |
| PubMed ID | 27144769 | Mgi Jnum | J:252467 |
| Mgi Id | MGI:6094669 | Doi | 10.1371/journal.pone.0154857 |
| Citation | Staber JM, et al. (2016) Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model. PLoS One 11(5):e0154857 |
| abstractText | BACKGROUND: Hemophilia A animal models have helped advance our understanding of factor VIII deficiency. Previously, factor VIII deficient mouse models were reported to have a normal life span without spontaneous bleeds. However, the bleeding frequency and survival in these animals has not been thoroughly evaluated. OBJECTIVE: To investigate the survival and lethal bleeding frequency in two strains of E-16 hemophilia A mice. METHODS: We prospectively studied factor VIII deficient hemizygous affected males (n = 83) and homozygous affected females (n = 55) for survival and bleeding frequency. Animals were evaluated for presence and location of bleeds as potential cause of death. RESULTS AND CONCLUSIONS: Hemophilia A mice had a median survival of 254 days, which is significantly shortened compared to wild type controls (p < 0.0001). In addition, the hemophilia A mice experienced hemorrhage in several tissues. This previously-underappreciated shortened survival in the hemophilia A murine model provides new outcomes for investigation of therapeutics and also reflects the shortened lifespan of patients if left untreated. |
