| First Author | Murphy JG | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 3 | Pages | 110264 |
| PubMed ID | 35045307 | Mgi Jnum | J:322569 |
| Mgi Id | MGI:6879546 | Doi | 10.1016/j.celrep.2021.110264 |
| Citation | Murphy JG, et al. (2022) R-type voltage-gated Ca(2+) channels mediate A-type K(+) current regulation of synaptic input in hippocampal dendrites. Cell Rep 38(3):110264 |
| abstractText | The subthreshold voltage-gated transient K(+) current (IA) carried by pore-forming Kv4.2 subunits regulates the propagation of synaptic input, dendritic excitability, and synaptic plasticity in CA1 pyramidal neuron dendrites of the hippocampus. We report that the Ca(2+) channel subunit Cav2.3 regulates IA in this cell type. We initially identified Cav2.3 as a Kv4.2-interacting protein in a proteomic screen and we confirmed Cav2.3-Kv4.2 complex association using multiple techniques. Functionally, Cav2.3 Ca(2+)-entry increases Kv4.2-mediated whole-cell current due to an increase in Kv4.2 surface expression. Using pharmacology and Cav2.3 knockout mice, we show that Cav2.3 regulates the dendritic gradient of IA. Furthermore, the loss of Cav2.3 function leads to the enhancement of AMPA receptor-mediated synaptic currents and NMDA receptor-mediated spine Ca(2+) influx. These results propose that Cav2.3 and Kv4.2 are integral constituents of an ion channel complex that affects synaptic function in the hippocampus. |
