| First Author | Hatakeyama S | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 11 | Pages | 2423-7 |
| PubMed ID | 11496122 | Mgi Jnum | J:103705 |
| Mgi Id | MGI:3610636 | Doi | 10.1097/00001756-200108080-00027 |
| Citation | Hatakeyama S, et al. (2001) Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels. Neuroreport 12(11):2423-7 |
| abstractText | The role of N-type Ca(2+) channels in nociceptive transmission was examined in genetically engineered mice lacking the alpha(1B) subunit of N-type channels and in their heterozygote and wild-type littermates. In alpha(1B)-deficient mice, N-type channel activities in dorsal root ganglion neurons and spinal synaptoneurosomes were eliminated without compensation by other types of voltage-dependent Ca(2+) channels. The alpha(1B)-deficient mice showed a diminution in the phase 2 nociceptive responses more extensively than in the phase 1 nociceptive responses of the formalin test. The alpha(1B)-deficient mice exhibited significantly increased thermal nociceptive thresholds in the hot plate test, but failed to increase mechanical nociceptive thresholds in the tail pinch test. These results suggest a crucial role of N-type channels in nociceptive transmission, especially for persistent pain like phase 2 of the formalin test and for nociception induced by thermal stimuli. |
