| First Author | Scoma HD | Year | 2011 |
| Journal | PLoS One | Volume | 6 |
| Issue | 9 | Pages | e25382 |
| PubMed ID | 21966515 | Mgi Jnum | J:177916 |
| Mgi Id | MGI:5296693 | Doi | 10.1371/journal.pone.0025382 |
| Citation | Scoma HD, et al. (2011) The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light. PLoS One 6(9):e25382 |
| abstractText | We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN. We have developed a knockout model of USP2 and found that exposure to low irradiance light at ZT12 increases phase delays of USP2(-/-) mice compared to wildtype. We additionally show that USP2b is in a complex with several clock components and regulates the stability and turnover of BMAL1, which in turn alters the expression of several CLOCK/BMAL1 controlled genes. Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes. |
