| First Author | Codrici E | Year | 2018 |
| Journal | J Immunol Res | Volume | 2018 |
| Pages | 2498576 | PubMed ID | 30246033 |
| Mgi Jnum | J:328443 | Mgi Id | MGI:6871647 |
| Doi | 10.1155/2018/2498576 | Citation | Codrici E, et al. (2018) Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases. J Immunol Res 2018:2498576 |
| abstractText | Caveolin-1 (CAV1) is the scaffold protein of caveolae, which are minute invaginations of the cell membrane that are involved in endocytosis, cell signaling, and endothelial-mediated inflammation. CAV1 has also been reported to have a dual role as either a tumor suppressor or tumor promoter, depending on the type of cancer. Inflammation is an important player in tumor progression, but the role of caveolin-1 in generating an inflammatory milieu remains poorly characterized. We used a caveolin-1-knockout (CAV1(-/-)) mouse model to assess the inflammatory status via the quantification of the pro- and anti-inflammatory cytokine levels, as well as the ability of circulating lymphocytes to respond to nonspecific stimuli by producing cytokines. Here, we report that the CAV1(-/-) mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-alpha, and IL-12p70 levels. CAV1(-/-) circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes. These results show that CAV1 involvement in cell homeostasis is more complex than previously revealed, as it plays a role in the inflammatory process. These findings indicate that the CAV1(-/-) mouse model could prove to be a useful tool for inflammation-related studies. |
