| First Author | Jung K | Year | 2012 |
| Journal | Anat Rec (Hoboken) | Volume | 295 |
| Issue | 2 | Pages | 196-200 |
| PubMed ID | 22213628 | Mgi Jnum | J:179372 |
| Mgi Id | MGI:5302132 | Doi | 10.1002/ar.21543 |
| Citation | Jung K, et al. (2012) Alveolar Epithelial Type II Cells and Their Microenvironment in the Caveolin-1-Deficient Mouse. Anat Rec (Hoboken) 295(2):196-200 |
| abstractText | Caveolin-1 (Cav-1) is highly expressed in alveolar epithelial type I (AE1) and endothelial cells of the alveolar region of the lung. Interestingly, alveolar epithelial type II (AE2) cells that are progenitors of the AE1 cells do not express Cav-1. We investigated whether genetic Cav-1 deficiency alters the phenotype of AE2 cells and their microenvironment using stereology. Total number, mean volume, and subcellular composition of the AE2 cells were not altered in Cav-1(-/-) when compared with wild-type mice. The alveolar septa were thickened and contained a significantly greater volume of extracellular matrix. Thus, AE2 cells as progenitors of AE1 cells are not critically involved in the severe pulmonary phenotype in Cav-1-deficient mice. Anat Rec, 2012. (c) 2011 Wiley Periodicals, Inc. |
