Other
16 Authors
- Mai S,
- Kang K,
- Zhang CC,
- Ma G,
- Feldmann M,
- Qin L,
- Zhang R,
- Luan Y,
- Aaronson SA,
- Yang WC,
- Hu HM,
- Pan PY,
- Mungamuri SK,
- van der Touw W,
- Bian G,
- Chen SH
| First Author | van der Touw W | Year | 2018 |
| Journal | J Immunol | Volume | 201 |
| Issue | 6 | Pages | 1727-1734 |
| PubMed ID | 30068593 | Mgi Jnum | J:265228 |
| Mgi Id | MGI:6199350 | Doi | 10.4049/jimmunol.1701450 |
| Citation | van der Touw W, et al. (2018) Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B. J Immunol 201(6):1727-1734 |
| abstractText | Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of multiple sclerosis. Despite an unclear mechanism of action, studies have shown that GA promotes protective Th2 immunity and stimulates release of cytokines that suppress autoimmunity. In this study, we demonstrate that GA interacts with murine paired Ig-like receptor B (PIR-B) on myeloid-derived suppressor cells and suppresses the STAT1/NF-kappaB pathways while promoting IL-10/TGF-beta cytokine release. In inflammatory bowel disease models, GA enhanced myeloid-derived suppressor cell-dependent CD4(+) regulatory T cell generation while reducing proinflammatory cytokine secretion. Human monocyte-derived macrophages responded to GA by reducing TNF-alpha production and promoting CD163 expression typical of alternative maturation despite the presence of GM-CSF. Furthermore, GA competitively interacts with leukocyte Ig-like receptors B (LILRBs), the human orthologs of PIR-B. Because GA limited proinflammatory activation of myeloid cells, therapeutics that target LILRBs represent novel treatment modalities for autoimmune indications. |
