| First Author | Singh R | Year | 2017 |
| Journal | J Immunol | Volume | 198 |
| Issue | 11 | Pages | 4394-4402 |
| PubMed ID | 28455436 | Mgi Jnum | J:247879 |
| Mgi Id | MGI:5927128 | Doi | 10.4049/jimmunol.1602010 |
| Citation | Singh R, et al. (2017) Egr2 and 3 Inhibit T-bet-Mediated IFN-gamma Production in T Cells. J Immunol 198(11):4394-4402 |
| abstractText | T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet function in CD4 and CD8 effector T cells. Egr2 and 3 were essential to suppress Th1 differentiation in Th2 and Th17 conditions in vitro and also to control IFN-gamma-producing CD4 and CD8 T cells in response to virus infection. Together with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expression was inhibited by Th1-inducing cytokines. We found that Egr2 and 3 physically interact with the T-box domain of T-bet, blocking T-bet DNA binding and inhibiting T-bet-mediated production of IFN-gamma. Thus, Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells. |
