| First Author | Weskamp G | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 12 | Pages | 1293-8 |
| PubMed ID | 17072319 | Mgi Jnum | J:116139 |
| Mgi Id | MGI:3693045 | Doi | 10.1038/ni1399 |
| Citation | Weskamp G, et al. (2006) ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol 7(12):1293-1298 |
| abstractText | CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo. Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies. |
