| First Author | Jongsma H | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 10 | Pages | 2215-9 |
| PubMed ID | 11447337 | Mgi Jnum | J:111024 |
| Mgi Id | MGI:3652634 | Doi | 10.1097/00001756-200107200-00034 |
| Citation | Jongsma H, et al. (2001) Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor. Neuroreport 12(10):2215-9 |
| abstractText | The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1. |
